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PH domain and leucine rich repeat protein phosphatase 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
O60346 [Direct mapping] PH domain leucine-rich repeat-containing protein phosphatase 1
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Enzymes ENZYME proteins Hydrolases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002667 [regulation of T cell anergy] GO:0003824 [catalytic activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006915 [apoptotic process] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009649 [entrainment of circadian clock] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043408 [regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0046328 [regulation of JNK cascade] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051898 [negative regulation of protein kinase B signaling] GO:1900744 [regulation of p38MAPK cascade]
