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PGR

GENERAL INFORMATION

Gene name

 PGR

Gene description

 Progesterone receptor

Protein class

 Cancer-related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, endometrial cancer)
HPA (cell line):Cell line enriched (T-47d)
HPA (normal tissue):Group enriched (cervix, uterine, endometrium, fallopian tube, smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression in female reproductive system and smooth muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA004751 , HPA008428 , HPA017176 , CAB000068 , CAB055100
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA004751
HPA008428
HPA017176
CAB000068
CAB055100

GENE INFORMATION

Gene name

 PGR (HGNC Symbol)

Synonyms

 NR3C3, PR

Description

 Progesterone receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

Chromosome

 11

Cytoband

 q22.1

Chromosome location (bp)

 101029624 - 101130524

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082175 (version 83.38)

Entrez gene

 5241

UniProt

 P06401 (UniProt - Evidence at protein level)

neXtProt

 NX_P06401

Antibodypedia

 PGR antibodies

PROTEIN BROWSER
PGR-001
PGR-002
PGR-006
PGR-010
PGR-201
PGR-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGR-001
ENSP00000325120
ENST00000325455
P06401 [Direct mapping]
Progesterone receptor
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Nuclear receptors
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001542 [ovulation from ovarian follicle]
GO:0002070 [epithelial cell maturation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005102 [receptor binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0030879 [mammary gland development]
GO:0038001 [paracrine signaling]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048286 [lung alveolus development]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060748 [tertiary branching involved in mammary gland duct morphogenesis]
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 933 aa
99 kDa 		No 0
PGR-002
ENSP00000436561
ENST00000534013
P06401 [Direct mapping]
Progesterone receptor
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005102 [receptor binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051117 [ATPase binding]
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 339 aa
38.8 kDa 		No 0
PGR-006
ENSP00000263463
ENST00000263463
P06401 [Direct mapping]
Progesterone receptor
Show all
Nuclear receptors
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005102 [receptor binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051117 [ATPase binding]
Show all
 831 aa
87.7 kDa 		No 0
PGR-010
ENSP00000487607
ENST00000632634
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
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 170 aa
19 kDa 		No 0
PGR-201
ENSP00000481227
ENST00000617858
A0A087WXR4 [Direct mapping]
Progesterone receptor
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 690 aa
71.2 kDa 		No 0
PGR-202
ENSP00000482698
ENST00000619228
Q8NG44 [Direct mapping]
Delta 3+6/2 progesterone receptor; Progesterone receptor; Progesterone receptor, isoform CRA_e
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Nuclear receptors
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 764 aa
79.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.