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EPB41L3

GENERAL INFORMATION

Gene name

 EPB41L3

Gene description

 Erythrocyte membrane protein band 4.1-like 3

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 24
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SCLC-21H, TIME, U-2 OS, U-251 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, often with a membranous pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA028605
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028605

GENE INFORMATION

Gene name

 EPB41L3 (HGNC Symbol)

Synonyms

 4.1B, DAL1, KIAA0987

Description

 Erythrocyte membrane protein band 4.1-like 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 p11.31

Chromosome location (bp)

 5392381 - 5630700

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082397 (version 83.38)

Entrez gene

 23136

UniProt

 Q9Y2J2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2J2

Antibodypedia

 EPB41L3 antibodies

PROTEIN BROWSER
«
EPB41L3-001
EPB41L3-002
EPB41L3-004
EPB41L3-007
EPB41L3-009
EPB41L3-010
EPB41L3-011
EPB41L3-012
EPB41L3-013
EPB41L3-014
EPB41L3-015
EPB41L3-017
EPB41L3-019
EPB41L3-020
EPB41L3-021
EPB41L3-022
EPB41L3-023
EPB41L3-024
EPB41L3-025
EPB41L3-032
EPB41L3-033
EPB41L3-201
EPB41L3-202
EPB41L3-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPB41L3-001
ENSP00000343158
ENST00000341928
Q9Y2J2 [Direct mapping]
Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0002175 [protein localization to paranode region of axon]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006915 [apoptotic process]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0008150 [biological_process]
GO:0008360 [regulation of cell shape]
GO:0019898 [extrinsic component of membrane]
GO:0030673 [axolemma]
GO:0030865 [cortical cytoskeleton organization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030913 [paranodal junction assembly]
GO:0033270 [paranode region of axon]
GO:0043217 [myelin maintenance]
GO:0044224 [juxtaparanode region of axon]
GO:0048812 [neuron projection morphogenesis]
GO:0071205 [protein localization to juxtaparanode region of axon]
GO:0072659 [protein localization to plasma membrane]
GO:0097481 [neuronal postsynaptic density]
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 1087 aa
120.7 kDa 		No 1
EPB41L3-002
ENSP00000488626
ENST00000545076
A8K968 [Target identity:100%; Query identity:100%]
cDNA FLJ77757
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
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 756 aa
84.7 kDa 		No 0
EPB41L3-004
ENSP00000442091
ENST00000540638
Q9Y2J2 [Direct mapping]
Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0002175 [protein localization to paranode region of axon]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006915 [apoptotic process]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0008150 [biological_process]
GO:0008360 [regulation of cell shape]
GO:0019898 [extrinsic component of membrane]
GO:0030673 [axolemma]
GO:0030865 [cortical cytoskeleton organization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030913 [paranodal junction assembly]
GO:0033270 [paranode region of axon]
GO:0043217 [myelin maintenance]
GO:0044224 [juxtaparanode region of axon]
GO:0048812 [neuron projection morphogenesis]
GO:0071205 [protein localization to juxtaparanode region of axon]
GO:0072659 [protein localization to plasma membrane]
Show all
 865 aa
96.5 kDa 		No 0
EPB41L3-007
ENSP00000464020
ENST00000580308
J3QR33 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 127 aa
13.8 kDa 		No 0
EPB41L3-009
ENSP00000464533
ENST00000578503
J3QS55 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 162 aa
18 kDa 		No 0
EPB41L3-010
ENSP00000462338
ENST00000582703
J3KS70 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 91 aa
9.9 kDa 		No 0
EPB41L3-011
ENSP00000463122
ENST00000580989
J3QKK4 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 125 aa
13.6 kDa 		No 0
EPB41L3-012
ENSP00000462692
ENST00000584651
J3QS55 [Direct mapping]
Band 4.1-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 162 aa
18 kDa 		No 0
EPB41L3-013
ENSP00000463289
ENST00000585142
J3QKY2 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 113 aa
12.3 kDa 		No 0
EPB41L3-014
ENSP00000461937
ENST00000581833
J3KRD1 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 117 aa
12.7 kDa 		No 0
EPB41L3-015
ENSP00000464148
ENST00000584015
J3QR33 [Direct mapping]
Band 4.1-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 127 aa
13.8 kDa 		No 0
EPB41L3-017
ENSP00000463707
ENST00000582592
J3QLU5 [Direct mapping]
Band 4.1-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 96 aa
10.2 kDa 		No 0
EPB41L3-019
ENSP00000462783
ENST00000584670
J3KT37 [Direct mapping]
Band 4.1-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 147 aa
16.8 kDa 		No 0
EPB41L3-020
ENSP00000487786
ENST00000581292
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 184 aa
20.2 kDa 		No 0
EPB41L3-021
ENSP00000487915
ENST00000581387
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 194 aa
21.8 kDa 		No 0
EPB41L3-022
ENSP00000488037
ENST00000580647
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 190 aa
21.3 kDa 		No 0
EPB41L3-023
ENSP00000488647
ENST00000578524
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 325 aa
35.4 kDa 		No 0
EPB41L3-024
ENSP00000488095
ENST00000579271
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 197 aa
21.9 kDa 		No 0
EPB41L3-025
ENSP00000487780
ENST00000580316
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 188 aa
20.9 kDa 		No 0
EPB41L3-032
ENSP00000464570
ENST00000579951
J3QS83 [Direct mapping]
Band 4.1-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 110 aa
11.7 kDa 		No 0
EPB41L3-033
ENSP00000464336
ENST00000580179
J3QRQ6 [Direct mapping]
Band 4.1-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 79 aa
8.5 kDa 		No 0
EPB41L3-201
ENSP00000341138
ENST00000342933
A0A0A0MRA8 [Direct mapping]
Band 4.1-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 918 aa
102.3 kDa 		No 0
EPB41L3-202
ENSP00000382981
ENST00000400111
B2RB02 [Direct mapping]
Band 4.1-like protein 3; cDNA, FLJ95236, highly similar to Homo sapiens differentially expressed in adenocarcinoma of the lung, mRNA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 503 aa
57.7 kDa 		No 0
EPB41L3-203
ENSP00000441174
ENST00000544123
Q9Y2J2 [Direct mapping]
Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0002175 [protein localization to paranode region of axon]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006915 [apoptotic process]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0008150 [biological_process]
GO:0008360 [regulation of cell shape]
GO:0019898 [extrinsic component of membrane]
GO:0030673 [axolemma]
GO:0030865 [cortical cytoskeleton organization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030913 [paranodal junction assembly]
GO:0033270 [paranode region of axon]
GO:0043217 [myelin maintenance]
GO:0044224 [juxtaparanode region of axon]
GO:0048812 [neuron projection morphogenesis]
GO:0071205 [protein localization to juxtaparanode region of axon]
GO:0072659 [protein localization to plasma membrane]
Show all
 883 aa
98.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.