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Most cancer tissues showed moderate nuclear staining with additional cytoplasmic membranous positivity in squamous cell carcinomas and few urothelial cancers. Few cases of urothelial and basal cell cancers displayed strong immunoreactivity. Several renal cell, lymphomas, liver, testis cancers and few gliomas were weakly stained or negative.
GENE INFORMATION
Gene name
NFE2L1 (HGNC Symbol)
Synonyms
FLJ00380, LCR-F1, NRF1, TCF11
Description
Nuclear factor, erythroid 2-like 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for ""nuclear respiratory factor 1"" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]