Tissue expression of NFE2L1 - Summary - The Human Protein Atlas

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NFE2L1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NFE2L1
Gene description	Nuclear factor, erythroid 2-like 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear and cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA065424
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NFE2L1 (HGNC Symbol)
Synonyms	FLJ00380, LCR-F1, NRF1, TCF11
Description	Nuclear factor, erythroid 2-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for ""nuclear respiratory factor 1"" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48048329 - 48061487
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000082641 (version 83.38)
Entrez gene	4779
UniProt	Q14494 (UniProt - Evidence at protein level)
neXtProt	NX_Q14494
Antibodypedia	NFE2L1 antibodies

PROTEIN BROWSER

NFE2L1-001	NFE2L1-002	NFE2L1-003	NFE2L1-006	NFE2L1-007	NFE2L1-008	NFE2L1-009	NFE2L1-010	NFE2L1-011	NFE2L1-014	NFE2L1-015	NFE2L1-016	NFE2L1-017	NFE2L1-018	NFE2L1-019	NFE2L1-020	NFE2L1-023	NFE2L1-024	NFE2L1-025

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NFE2L1-001 ENSP00000354855 ENST00000362042	Q14494 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Transcription factors Basic domains Show all	GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006783 [heme biosynthetic process] GO:0006954 [inflammatory response] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0030218 [erythrocyte differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	772 aa 84.7 kDa	Yes	0
NFE2L1-002 ENSP00000461960 ENST00000585291	Q14494 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Transcription factors Basic domains Show all	GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006783 [heme biosynthetic process] GO:0006954 [inflammatory response] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	742 aa 81.5 kDa	Yes	0
NFE2L1-003 ENSP00000350072 ENST00000357480	Q14494 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Transcription factors Basic domains Show all	GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006783 [heme biosynthetic process] GO:0006954 [inflammatory response] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	742 aa 81.5 kDa	Yes	0
NFE2L1-006 ENSP00000355190 ENST00000361665	J9JIE5 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	761 aa 83.3 kDa	Yes	0
NFE2L1-007 ENSP00000464446 ENST00000582155	B4DYE1 [Direct mapping] Nuclear factor erythroid 2-related factor 1; cDNA FLJ53241, highly similar to Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	584 aa 64.2 kDa	No	0
NFE2L1-008 ENSP00000463291 ENST00000583378	J3QKY3 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	573 aa 62.8 kDa	No	0
NFE2L1-009 ENSP00000445811 ENST00000536222	F5H1B7 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	616 aa 67.4 kDa	No	0
NFE2L1-010 ENSP00000463657 ENST00000584137	J3QLQ1 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		83 aa 9.5 kDa	Yes	0
NFE2L1-011 ENSP00000463960 ENST00000585062	J3QQY8 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		99 aa 11.3 kDa	Yes	0
NFE2L1-014 ENSP00000463836 ENST00000577431	J3QQQ1 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		161 aa 17.3 kDa	No	0
NFE2L1-015 ENSP00000462444 ENST00000579537	J3KSE0 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		63 aa 6.6 kDa	No	0
NFE2L1-016 ENSP00000464018 ENST00000583210	J3QR31 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		23 aa 2.5 kDa	No	0
NFE2L1-017 ENSP00000464203 ENST00000580050	J3QRG7 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		111 aa 12 kDa	No	0
NFE2L1-018 ENSP00000463744 ENST00000580037	J3QQH8 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		47 aa 5.1 kDa	No	0
NFE2L1-019 ENSP00000461971 ENST00000581319	J3KRF3 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	133 aa 14.7 kDa	No	0
NFE2L1-020 ENSP00000462003 ENST00000579889	A0A0G2JLG9 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		9 aa 1.1 kDa	No	0
NFE2L1-023 ENSP00000462253 ENST00000581441		Predicted intracellular proteins Show all		4 aa 0.5 kDa	No	0
NFE2L1-024 ENSP00000462610 ENST00000577411	J3KSR3 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		63 aa 6.7 kDa	No	0
NFE2L1-025 ENSP00000462971 ENST00000584634	J3KTG6 [Direct mapping] Nuclear factor erythroid 2-related factor 1 Show all	Predicted intracellular proteins Show all		19 aa 2.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.