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Most cancer cells showed weak to moderate cytoplasmic positivity. Cases of thyroid and urothelial tumors displayed strong staining. Additional membranous positivity was observed in a few cancers.
Cancer cells displayed moderate to strong cytoplasmic staining. Additional nuclear positivity was observed in a cancers.
GENE INFORMATION
Gene name
ULK2 (HGNC Symbol)
Synonyms
ATG1B, KIAA0623, Unc51.2
Description
Unc-51 like autophagy activating kinase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]