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DIS3

GENERAL INFORMATION

Gene name

 DIS3

Gene description

 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous mainly nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039281
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DIS3 (HGNC Symbol)

Synonyms

 dis3p, EXOSC11, KIAA1008, RRP44

Description

 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q21.33

Chromosome location (bp)

 72752169 - 72782096

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083520 (version 83.38)

Entrez gene

 22894

UniProt

 Q9Y2L1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2L1

Antibodypedia

 DIS3 antibodies

PROTEIN BROWSER
DIS3-001
DIS3-002
DIS3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DIS3-001
ENSP00000366997
ENST00000377767
Q9Y2L1 [Direct mapping]
Exosome complex exonuclease RRP44
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0003723 [RNA binding]
GO:0004519 [endonuclease activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006402 [mRNA catabolic process]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016075 [rRNA catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0043547 [positive regulation of GTPase activity]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 958 aa
109 kDa 		No 0
DIS3-002
ENSP00000367011
ENST00000377780
Q9Y2L1 [Direct mapping]
Exosome complex exonuclease RRP44
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0003723 [RNA binding]
GO:0004519 [endonuclease activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006402 [mRNA catabolic process]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016075 [rRNA catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0043547 [positive regulation of GTPase activity]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 928 aa
105 kDa 		No 0
DIS3-201
ENSP00000440058
ENST00000545453
G3V1J5 [Direct mapping]
Exosome complex exonuclease RRP44; KIAA1008, isoform CRA_c
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0006402 [mRNA catabolic process]
Show all
 796 aa
90.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.