Expression of EPYC in cancer - Summary - The Human Protein Atlas

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EPYC

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EPYC
Gene description	Epiphycan
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (ovarian cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High expression in extracellular matrix.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA038212 , HPA045455
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038212	HPA045455

GENE INFORMATION
Gene name	EPYC (HGNC Symbol)
Synonyms	DSPG3, Pg-Lb, SLRR3B
Description	Epiphycan (HGNC Symbol)
Entrez gene summary	Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.33
Chromosome location (bp)	90963679 - 91005026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083782 (version 83.38)
Entrez gene	1833
UniProt	Q99645 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99645
Antibodypedia	EPYC antibodies

PROTEIN BROWSER

EPYC-001	EPYC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPYC-001 ENSP00000261172 ENST00000261172	Q99645 [Direct mapping] Epiphycan A0A024RBC3 [Target identity:100%; Query identity:100%] Dermatan sulfate proteoglycan 3, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007565 [female pregnancy] GO:0008201 [heparin binding] Show all	322 aa 36.6 kDa	Yes	0
EPYC-002 ENSP00000448272 ENST00000551767	F8VSI4 [Direct mapping] Epiphycan Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	234 aa 26.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.