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ZMPSTE24

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GENERAL INFORMATION

Gene name

 ZMPSTE24

Gene description

 Zinc metallopeptidase STE24

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the Golgi apparatus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA006988
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the Golgi apparatus.

Main location

 Cytosol (approved)

Additional location

 Golgi apparatus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006988 A-431 Golgi apparatus
Cytosol
HPA006988 U-2 OS Cytosol
HPA006988 U-251 MG Cytosol

GENE INFORMATION

Gene name

 ZMPSTE24 (HGNC Symbol)

Synonyms

 FACE-1, HGPS, PRO1, STE24, Ste24p

Description

 Zinc metallopeptidase STE24 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 40258107 - 40294184

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000084073 (version 83.38)

Entrez gene

 10269

UniProt

 O75844 (UniProt - Evidence at protein level)

neXtProt

 NX_O75844

Antibodypedia

 ZMPSTE24 antibodies

PROTEIN BROWSER
ZMPSTE24-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZMPSTE24-001
ENSP00000361845
ENST00000372759
O75844 [Direct mapping]
CAAX prenyl protease 1 homolog
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005637 [nuclear inner membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0006998 [nuclear envelope organization]
GO:0008235 [metalloexopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030327 [prenylated protein catabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:0071586 [CAAX-box protein processing]
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 475 aa
54.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.