Expression of ZMPSTE24 in cancer - Summary - The Human Protein Atlas

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ZMPSTE24

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZMPSTE24
Gene description	Zinc metallopeptidase STE24
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA006988
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and thyroid cancer (unfavourable).
Liver cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006988

GENE INFORMATION
Gene name	ZMPSTE24 (HGNC Symbol)
Synonyms	FACE-1, HGPS, PRO1, STE24, Ste24p
Description	Zinc metallopeptidase STE24 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	40258107 - 40294184
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084073 (version 83.38)
Entrez gene	10269
UniProt	O75844 (UniProt - Evidence at protein level)
neXtProt	NX_O75844
Antibodypedia	ZMPSTE24 antibodies

PROTEIN BROWSER

ZMPSTE24-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZMPSTE24-001 ENSP00000361845 ENST00000372759	O75844 [Direct mapping] CAAX prenyl protease 1 homolog Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005637 [nuclear inner membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0006998 [nuclear envelope organization] GO:0008235 [metalloexopeptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030327 [prenylated protein catabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0071586 [CAAX-box protein processing] Show all	475 aa 54.8 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.