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CD59

GENERAL INFORMATION

Gene name

 CD59

Gene description

 CD59 molecule, complement regulatory protein

Protein class

 Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in selected tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA026494 , CAB001448
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CD59 (HGNC Symbol)

Synonyms

 16.3A5, EJ16, EJ30, EL32, G344, MIC11, MIN1, MIN2, MIN3, MSK21, p18-20

Description

 CD59 molecule, complement regulatory protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 33698261 - 33736445

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085063 (version 83.38)

Entrez gene

 966

UniProt

 P13987 (UniProt - Evidence at protein level)

neXtProt

 NX_P13987

Antibodypedia

 CD59 antibodies

PROTEIN BROWSER
CD59-001
CD59-002
CD59-003
CD59-005
CD59-006
CD59-007
CD59-008
CD59-009
CD59-010
CD59-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD59-001
ENSP00000340210
ENST00000351554
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-002
ENSP00000379191
ENST00000395850
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0001971 [negative regulation of activation of membrane attack complex]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042383 [sarcolemma]
GO:0043066 [negative regulation of apoptotic process]
GO:0043218 [compact myelin]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-003
ENSP00000404822
ENST00000415002
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-005
ENSP00000432942
ENST00000527577
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-006
ENSP00000434617
ENST00000528700
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-007
ENSP00000402425
ENST00000426650
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-008
ENSP00000403511
ENST00000445143
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-009
ENSP00000410182
ENST00000437761
P13987 [Direct mapping]
CD59 glycoprotein
Q6FHM9 [Target identity:100%; Query identity:100%]
CD59 antigen, complement regulatory protein, isoform CRA_b; CD59 protein; cDNA, FLJ92039, Homo sapiens CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59), mRNA
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001848 [complement binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030449 [regulation of complement activation]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031982 [vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 128 aa
14.2 kDa 		Yes 1
CD59-010
ENSP00000436737
ENST00000533403
E9PI80 [Direct mapping]
CD59 glycoprotein
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001848 [complement binding]
GO:0005886 [plasma membrane]
GO:0030449 [regulation of complement activation]
Show all
 119 aa
13 kDa 		Yes 0
CD59-012
ENSP00000432362
ENST00000534312
E9PR17 [Direct mapping]
CD59 glycoprotein
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001848 [complement binding]
GO:0005886 [plasma membrane]
GO:0030449 [regulation of complement activation]
Show all
 130 aa
14.5 kDa 		Yes 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.