Expression of BCORL1 in cancer - Summary - The Human Protein Atlas

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BCORL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCORL1
Gene description	BCL6 corepressor-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AN3-CA)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA031775 , HPA031777
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031775	HPA031777

GENE INFORMATION
Gene name	BCORL1 (HGNC Symbol)
Synonyms	CXorf10, FLJ11362
Description	BCL6 corepressor-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	129981107 - 130058083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085185 (version 83.38)
Entrez gene	63035
UniProt	Q5H9F3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5H9F3
Antibodypedia	BCORL1 antibodies

PROTEIN BROWSER

BCORL1-001	BCORL1-002	BCORL1-003	BCORL1-004	BCORL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCORL1-001 ENSP00000218147 ENST00000218147	Q5H9F3 [Direct mapping] BCL-6 corepressor-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016568 [chromatin modification] Show all	1711 aa 182.5 kDa	No	0
BCORL1-002 ENSP00000484149 ENST00000607874	A0A087X1F0 [Direct mapping] BCL-6 corepressor-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.2 kDa	No	0
BCORL1-003 ENSP00000399483 ENST00000456822	A0A075B6Q3 [Direct mapping] BCL-6 corepressor-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1385 aa 150.6 kDa	No	0
BCORL1-004 ENSP00000416520 ENST00000441294	H7C4B2 [Direct mapping] BCL-6 corepressor-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		741 aa 79.3 kDa	No	0
BCORL1-201 ENSP00000437775 ENST00000540052	Q5H9F3 [Direct mapping] BCL-6 corepressor-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016568 [chromatin modification] Show all	1711 aa 182.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.