Thyroid carcinomas and carcinoids were strongly stained in a few cases.
Moderate to strong cytoplasmic and membranous staining was observed in several liver, prostate, colorectal and thyroid cancers. Remaining malignant tissues were in general negative.
Colorectal- and liver cancers displayed moderate membranous and cytoplasmic immunoreactivity. Remaining malignant tissues were negative.
ABCB1 (HGNC Symbol)
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]