Expression of ABCB1 in cancer - Summary

GENERAL INFORMATION
Gene name	ABCB1
Gene description	ATP-binding cassette, sub-family B (MDR/TAP), member 1
Protein class	Cancer-related genes CD markers Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (CACO-2, HEL, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (adrenal gland, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in a few tissues, most abundant in adrenal gland. Distinct expression in endothelial cells of CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA002199 , CAB001716
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002199	CAB001716

GENE INFORMATION
Gene name	ABCB1 (HGNC Symbol)
Synonyms	ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q21.12
Chromosome location (bp)	87503633 - 87713323
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085563 (version 83.38)
Entrez gene	5243
UniProt	P08183 (UniProt - Evidence at protein level)
neXtProt	NX_P08183
Antibodypedia	ABCB1 antibodies

PROTEIN BROWSER

ABCB1-001	ABCB1-003	ABCB1-201	ABCB1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCB1-001 ENSP00000265724 ENST00000265724	P08183 [Direct mapping] Multidrug resistance protein 1 A4D1D2 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c; Multidrug resistance protein 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008559 [xenobiotic-transporting ATPase activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042908 [xenobiotic transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072089 [stem cell proliferation] Show all	1280 aa 141.5 kDa	No	>9
ABCB1-003 ENSP00000399419 ENST00000416177	E7EWT8 [Direct mapping] Multidrug resistance protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0055085 [transmembrane transport] Show all	48 aa 5.7 kDa	No	0
ABCB1-201 ENSP00000444095 ENST00000543898	P08183 [Direct mapping] Multidrug resistance protein 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008559 [xenobiotic-transporting ATPase activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042908 [xenobiotic transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072089 [stem cell proliferation] Show all	1216 aa 134 kDa	No	>9
ABCB1-202 ENSP00000478255 ENST00000622132	P08183 [Direct mapping] Multidrug resistance protein 1 A4D1D2 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c; Multidrug resistance protein 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008559 [xenobiotic-transporting ATPase activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042908 [xenobiotic transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072089 [stem cell proliferation] Show all	1280 aa 141.5 kDa	No	>9