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ATG16L1

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GENERAL INFORMATION

Gene name

 ATG16L1

Gene description

 Autophagy related 16-like 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA012577
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA012577 A-431 Cytosol
HPA012577 Hep G2 Cytosol

GENE INFORMATION

Gene name

 ATG16L1 (HGNC Symbol)

Synonyms

 APG16L, ATG16A, ATG16L, FLJ10035, WDR30

Description

 Autophagy related 16-like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 233210051 - 233295674

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085978 (version 83.38)

Entrez gene

 55054

UniProt

 Q676U5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q676U5

Antibodypedia

 ATG16L1 antibodies

PROTEIN BROWSER
ATG16L1-001
ATG16L1-003
ATG16L1-004
ATG16L1-005
ATG16L1-006
ATG16L1-007
ATG16L1-012
ATG16L1-013
ATG16L1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG16L1-001
ENSP00000375872
ENST00000392017
Q676U5 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0039689 [negative stranded viral RNA replication]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
Show all
 607 aa
68.3 kDa 		No 0
ATG16L1-003
ENSP00000375875
ENST00000392020
Q676U5 [Direct mapping]
Autophagy-related protein 16-1
A0A024R494 [Target identity:100%; Query identity:100%]
ATG16 autophagy related 16-like 1 (S. cerevisiae), isoform CRA_b
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0039689 [negative stranded viral RNA replication]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
Show all
 588 aa
66.3 kDa 		No 0
ATG16L1-004
ENSP00000362625
ENST00000373525
Q676U5 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0039689 [negative stranded viral RNA replication]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
Show all
 428 aa
47.7 kDa 		No 0
ATG16L1-005
ENSP00000375873
ENST00000392018
E7EVC7 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0005515 [protein binding]
GO:0039689 [negative stranded viral RNA replication]
Show all
 624 aa
70 kDa 		No 0
ATG16L1-006
ENSP00000398773
ENST00000419681
C9JAY7 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0039689 [negative stranded viral RNA replication]
Show all
 164 aa
18.7 kDa 		No 0
ATG16L1-007
ENSP00000409215
ENST00000444735
C9JK97 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0039689 [negative stranded viral RNA replication]
Show all
 178 aa
20.1 kDa 		No 0
ATG16L1-012
ENSP00000397512
ENST00000431917
C9J8C6 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0039689 [negative stranded viral RNA replication]
Show all
 55 aa
6.5 kDa 		No 0
ATG16L1-013
ENSP00000412046
ENST00000417017
C9J1B2 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0039689 [negative stranded viral RNA replication]
Show all
 187 aa
22 kDa 		No 0
ATG16L1-201
ENSP00000318259
ENST00000347464
Q676U5 [Direct mapping]
Autophagy-related protein 16-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000421 [autophagosome membrane]
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005930 [axoneme]
GO:0015031 [protein transport]
GO:0016236 [macroautophagy]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0039689 [negative stranded viral RNA replication]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
Show all
 444 aa
49.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.