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Most cancer tissues showed weak to moderate cytoplasmic and membranous immunoreactivity. Lymphomas, gliomas and hepatocellular carcinomas were mostly negative.
GENE INFORMATION
Gene name
ATG16L1 (HGNC Symbol)
Synonyms
APG16L, ATG16A, ATG16L, FLJ10035, WDR30
Description
Autophagy related 16-like 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]