Expression of IPO11 in cancer - Summary - The Human Protein Atlas

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IPO11

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IPO11
Gene description	Importin 11
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA067097
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067097

GENE INFORMATION
Gene name	IPO11 (HGNC Symbol)
Synonyms	RanBP11
Description	Importin 11 (HGNC Symbol)
Entrez gene summary	Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Chromosome	5
Cytoband	q12.1
Chromosome location (bp)	62403972 - 62628582
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086200 (version 83.38)
Entrez gene	51194
UniProt	Q9UI26 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UI26
Antibodypedia	IPO11 antibodies

PROTEIN BROWSER

IPO11-001	IPO11-002	IPO11-004	IPO11-006	IPO11-007	IPO11-008	IPO11-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IPO11-001 ENSP00000316651 ENST00000325324	Q9UI26 [Direct mapping] Importin-11 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] GO:0008565 [protein transporter activity] GO:0042991 [transcription factor import into nucleus] Show all	975 aa 112.5 kDa	No	0
IPO11-002 ENSP00000386992 ENST00000409296	Q9UI26 [Direct mapping] Importin-11 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005829 [cytosol] GO:0006610 [ribosomal protein import into nucleus] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] GO:0008565 [protein transporter activity] GO:0042991 [transcription factor import into nucleus] Show all	1015 aa 117 kDa	No	0
IPO11-004 ENSP00000387039 ENST00000409534	E7EMB7 [Direct mapping] Importin-11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	94 aa 10.9 kDa	No	0
IPO11-006 ENSP00000421517 ENST00000511713	H0Y8M5 [Direct mapping] Importin-11 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	160 aa 18.1 kDa	Yes	0
IPO11-007 ENSP00000427129 ENST00000514647	D6RCN7 [Direct mapping] Importin-11 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] Show all	149 aa 17.1 kDa	No	0
IPO11-008 ENSP00000425573 ENST00000505902	D6RCQ2 [Direct mapping] Importin-11 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] Show all	64 aa 7.2 kDa	No	0
IPO11-009 ENSP00000427274 ENST00000506200	D6RJB1 [Direct mapping] Importin-11 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] Show all	162 aa 18.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.