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IPO11

GENERAL INFORMATION

Gene name

 IPO11

Gene description

 Importin 11

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA067097
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IPO11 (HGNC Symbol)

Synonyms

 RanBP11

Description

 Importin 11 (HGNC Symbol)

Entrez gene summary

 Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

Chromosome

 5

Cytoband

 q12.1

Chromosome location (bp)

 62403972 - 62628582

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086200 (version 83.38)

Entrez gene

 51194

UniProt

 Q9UI26 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI26

Antibodypedia

 IPO11 antibodies

PROTEIN BROWSER
IPO11-001
IPO11-002
IPO11-004
IPO11-006
IPO11-007
IPO11-008
IPO11-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IPO11-001
ENSP00000316651
ENST00000325324
Q9UI26 [Direct mapping]
Importin-11
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0042991 [transcription factor import into nucleus]
Show all
 975 aa
112.5 kDa 		No 0
IPO11-002
ENSP00000386992
ENST00000409296
Q9UI26 [Direct mapping]
Importin-11
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0042991 [transcription factor import into nucleus]
Show all
 1015 aa
117 kDa 		No 0
IPO11-004
ENSP00000387039
ENST00000409534
E7EMB7 [Direct mapping]
Importin-11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 94 aa
10.9 kDa 		No 0
IPO11-006
ENSP00000421517
ENST00000511713
H0Y8M5 [Direct mapping]
Importin-11
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 160 aa
18.1 kDa 		Yes 0
IPO11-007
ENSP00000427129
ENST00000514647
D6RCN7 [Direct mapping]
Importin-11
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 149 aa
17.1 kDa 		No 0
IPO11-008
ENSP00000425573
ENST00000505902
D6RCQ2 [Direct mapping]
Importin-11
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 64 aa
7.2 kDa 		No 0
IPO11-009
ENSP00000427274
ENST00000506200
D6RJB1 [Direct mapping]
Importin-11
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 162 aa
18.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.