Cell atlas - EIF2AK1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EIF2AK1
Gene description	Eukaryotic translation initiation factor 2-alpha kinase 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA016496 , HPA061675
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA016496	A-431	Nucleoplasm
HPA016496	U-2 OS	Nucleoplasm
HPA016496	U-251 MG	Nucleoplasm
HPA061675	Hep G2	Nucleus
HPA061675	Hep G2	Cytosol
HPA061675	MCF7	Nucleus

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000029613 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA016496	NIH 3T3	No staining

GENE INFORMATION
Gene name	EIF2AK1 (HGNC Symbol)
Synonyms	HRI, KIAA1369
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	7
Cytoband	p22.1
Chromosome location (bp)	6022244 - 6059230
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086232 (version 83.38)
Entrez gene	27102
UniProt	Q9BQI3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQI3
Antibodypedia	EIF2AK1 antibodies

PROTEIN BROWSER

EIF2AK1-001	EIF2AK1-004	EIF2AK1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2AK1-001 ENSP00000199389 ENST00000199389	Q9BQI3 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 1 A0A024QZU1 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 2-alpha kinase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002526 [acute inflammatory response] GO:0004672 [protein kinase activity] GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0006950 [response to stress] GO:0008285 [negative regulation of cell proliferation] GO:0009605 [response to external stimulus] GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation] GO:0010999 [regulation of eIF2 alpha phosphorylation by heme] GO:0020037 [heme binding] GO:0030225 [macrophage differentiation] GO:0042803 [protein homodimerization activity] GO:0045993 [negative regulation of translational initiation by iron] GO:0046501 [protoporphyrinogen IX metabolic process] GO:0046777 [protein autophosphorylation] GO:0046984 [regulation of hemoglobin biosynthetic process] GO:0046986 [negative regulation of hemoglobin biosynthetic process] GO:0055072 [iron ion homeostasis] Show all	630 aa 71.1 kDa	No	0
EIF2AK1-004 ENSP00000397590 ENST00000446699	C9J7U7 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.5 kDa	No	0
EIF2AK1-011 ENSP00000392734 ENST00000422786	H7C033 [Direct mapping] Eukaryotic translation initiation factor 2-alpha kinase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.5 kDa	Yes	0