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MRPL28

GENERAL INFORMATION

Gene name

 MRPL28

Gene description

 Mitochondrial ribosomal protein L28

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA030594 , HPA055589 , CAB033542
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030594
HPA055589
CAB033542

GENE INFORMATION

Gene name

 MRPL28 (HGNC Symbol)

Synonyms

 MAAT1, p15

Description

 Mitochondrial ribosomal protein L28 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 367384 - 370527

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086504 (version 83.38)

Entrez gene

 10573

UniProt

 Q13084 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13084

Antibodypedia

 MRPL28 antibodies

PROTEIN BROWSER
MRPL28-006
MRPL28-008
MRPL28-009
MRPL28-010
MRPL28-011
MRPL28-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL28-006
ENSP00000199706
ENST00000199706
Q13084 [Direct mapping]
39S ribosomal protein L28, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 256 aa
30.2 kDa 		No 0
MRPL28-008
ENSP00000374326
ENST00000389675
Q13084 [Direct mapping]
39S ribosomal protein L28, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 256 aa
30.2 kDa 		No 0
MRPL28-009
ENSP00000390399
ENST00000447696
Q4TT37 [Direct mapping]
39S ribosomal protein L28, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 218 aa
25.9 kDa 		No 0
MRPL28-010
ENSP00000398684
ENST00000441883
A2IDC6 [Direct mapping]
39S ribosomal protein L28, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 240 aa
28.5 kDa 		No 0
MRPL28-011
ENSP00000395305
ENST00000450882
A2IDC7 [Direct mapping]
39S ribosomal protein L28, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 194 aa
23.1 kDa 		No 0
MRPL28-012
ENSP00000414038
ENST00000429738
A2IDC5 [Direct mapping]
39S ribosomal protein L28, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 48 aa
5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.