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ITPKC

GENERAL INFORMATION

Gene name

 ITPKC

Gene description

 Inositol-trisphosphate 3-kinase C

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA050760 , HPA053003
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ITPKC (HGNC Symbol)

Synonyms

 IP3-3KC, IP3KC

Description

 Inositol-trisphosphate 3-kinase C (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 40717103 - 40740860

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086544 (version 83.38)

Entrez gene

 80271

UniProt

 Q96DU7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DU7

Antibodypedia

 ITPKC antibodies

PROTEIN BROWSER
ITPKC-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITPKC-001
ENSP00000263370
ENST00000263370
Q96DU7 [Direct mapping]
Inositol-trisphosphate 3-kinase C
A0A024R0N8 [Target identity:100%; Query identity:100%]
Inositol 1,4,5-trisphosphate 3-kinase C, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 683 aa
75.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.