Expression of CEACAM6 in cancer - Summary

GENERAL INFORMATION
Gene name	CEACAM6
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Protein class	Cancer-related genes CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (A549)
HPA (normal tissue):	Group enriched (bone marrow, colon, esophagus, gallbladder, lung, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues. Distinct expression in a subset of leukocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA011041 , CAB008370
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011041	CAB008370

GENE INFORMATION
Gene name	CEACAM6 (HGNC Symbol)
Synonyms	CD66c, NCA
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41750977 - 41772208
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086548 (version 83.38)
Entrez gene	4680
UniProt	P40199 (UniProt - Evidence at protein level)
neXtProt	NX_P40199
Antibodypedia	CEACAM6 antibodies

PROTEIN BROWSER

CEACAM6-001	CEACAM6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM6-001 ENSP00000199764 ENST00000199764	P40199 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007596 [blood coagulation] GO:0031225 [anchored component of membrane] GO:0050900 [leukocyte migration] Show all	344 aa 37.2 kDa	Yes	1
CEACAM6-002 ENSP00000469752 ENST00000595740	M0QYD3 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 6 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 3.7 kDa	No	0