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PPEF1

GENERAL INFORMATION

Gene name

 PPEF1

Gene description

 Protein phosphatase, EF-hand calcium binding domain 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, HeLa)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA034577
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034577

GENE INFORMATION

Gene name

 PPEF1 (HGNC Symbol)

Synonyms

 PPEF, PPP7CA

Description

 Protein phosphatase, EF-hand calcium binding domain 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.13

Chromosome location (bp)

 18675909 - 18827921

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086717 (version 83.38)

Entrez gene

 5475

UniProt

 O14829 (UniProt - Evidence at protein level)

neXtProt

 NX_O14829

Antibodypedia

 PPEF1 antibodies

PROTEIN BROWSER
PPEF1-001
PPEF1-004
PPEF1-007
PPEF1-008
PPEF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPEF1-001
ENSP00000354871
ENST00000361511
O14829 [Direct mapping]
Serine/threonine-protein phosphatase with EF-hands 1
A0A024RBZ9 [Target identity:100%; Query identity:100%]
Serine/threonine-protein phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016787 [hydrolase activity]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030145 [manganese ion binding]
GO:0050906 [detection of stimulus involved in sensory perception]
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 653 aa
75.8 kDa 		No 0
PPEF1-004
ENSP00000418623
ENST00000496075
F8WC69 [Direct mapping]
Serine/threonine-protein phosphatase
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Predicted intracellular proteins
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GO:0004721 [phosphoprotein phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016787 [hydrolase activity]
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 179 aa
20.7 kDa 		No 0
PPEF1-007
ENSP00000419948
ENST00000472826
C9JY08 [Direct mapping]
Serine/threonine-protein phosphatase with EF-hands 1
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Predicted intracellular proteins
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 96 aa
11.3 kDa 		No 0
PPEF1-008
ENSP00000419273
ENST00000470157
H7C592 [Direct mapping]
Serine/threonine-protein phosphatase with EF-hands 1
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 115 aa
13.4 kDa 		No 0
PPEF1-201
ENSP00000341892
ENST00000349874
O14829 [Direct mapping]
Serine/threonine-protein phosphatase with EF-hands 1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016787 [hydrolase activity]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030145 [manganese ion binding]
GO:0050906 [detection of stimulus involved in sensory perception]
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 591 aa
68.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.