Tissue expression of PPEF1 - Summary - The Human Protein Atlas

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PPEF1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PPEF1
Gene description	Protein phosphatase, EF-hand calcium binding domain 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (brain)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA034577
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain)

GENE INFORMATION
Gene name	PPEF1 (HGNC Symbol)
Synonyms	PPEF, PPP7CA
Description	Protein phosphatase, EF-hand calcium binding domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p22.13
Chromosome location (bp)	18675909 - 18827921
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086717 (version 83.38)
Entrez gene	5475
UniProt	O14829 (UniProt - Evidence at protein level)
neXtProt	NX_O14829
Antibodypedia	PPEF1 antibodies

PROTEIN BROWSER

PPEF1-001	PPEF1-004	PPEF1-007	PPEF1-008	PPEF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPEF1-001 ENSP00000354871 ENST00000361511	O14829 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 A0A024RBZ9 [Target identity:100%; Query identity:100%] Serine/threonine-protein phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005506 [iron ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0016787 [hydrolase activity] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030145 [manganese ion binding] GO:0050906 [detection of stimulus involved in sensory perception] Show all	653 aa 75.8 kDa	No	0
PPEF1-004 ENSP00000418623 ENST00000496075	F8WC69 [Direct mapping] Serine/threonine-protein phosphatase Show all	Predicted intracellular proteins Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016787 [hydrolase activity] Show all	179 aa 20.7 kDa	No	0
PPEF1-007 ENSP00000419948 ENST00000472826	C9JY08 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 Show all	Predicted intracellular proteins Show all		96 aa 11.3 kDa	No	0
PPEF1-008 ENSP00000419273 ENST00000470157	H7C592 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	115 aa 13.4 kDa	No	0
PPEF1-201 ENSP00000341892 ENST00000349874	O14829 [Direct mapping] Serine/threonine-protein phosphatase with EF-hands 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005506 [iron ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0007603 [phototransduction, visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0016787 [hydrolase activity] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030145 [manganese ion binding] GO:0050906 [detection of stimulus involved in sensory perception] Show all	591 aa 68.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.