Cell atlas - ALG9 - The Human Protein Atlas

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ALG9

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	ALG9
Gene description	ALG9, alpha-1,2-mannosyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038575
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038575	CACO-2	No staining
	HPA038575	U-2 OS	Endoplasmic reticulum
	HPA038575	U-251 MG	No staining

GENE INFORMATION
Gene name	ALG9 (HGNC Symbol)
Synonyms	DIBD1
Description	ALG9, alpha-1,2-mannosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Chromosome	11
Cytoband	q23.1
Chromosome location (bp)	111782195 - 111871581
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086848 (version 83.38)
Entrez gene	79796
UniProt	Q9H6U8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6U8
Antibodypedia	ALG9 antibodies

PROTEIN BROWSER

ALG9-001	ALG9-006	ALG9-010	ALG9-011	ALG9-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG9-001 ENSP00000484200 ENST00000614444	Q9H6U8 [Direct mapping] Alpha-1,2-mannosyltransferase ALG9 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0052918 [dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0052926 [dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0097502 [mannosylation] Show all	611 aa 69.9 kDa	No	>9
ALG9-006 ENSP00000482437 ENST00000616540	Q9H6U8 [Direct mapping] Alpha-1,2-mannosyltransferase ALG9 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0052918 [dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0052926 [dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0097502 [mannosylation] Show all	618 aa 70.8 kDa	No	>9
ALG9-010 ENSP00000381090 ENST00000398006	Q9H6U8 [Direct mapping] Alpha-1,2-mannosyltransferase ALG9 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0052918 [dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0052926 [dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0097502 [mannosylation] Show all	440 aa 50.8 kDa	Yes	6
ALG9-011 ENSP00000435517 ENST00000531154	Q9H6U8 [Direct mapping] Alpha-1,2-mannosyltransferase ALG9 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0052918 [dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0052926 [dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity] GO:0097502 [mannosylation] Show all	447 aa 51.7 kDa	Yes	6
ALG9-017 ENSP00000432442 ENST00000532425	H0YCW6 [Direct mapping] Alpha-1,2-mannosyltransferase ALG9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0097502 [mannosylation] Show all	207 aa 24.2 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.