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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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OGFOD1
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

OGFOD1

Gene description

2-oxoglutarate and iron-dependent oxygenase domain containing 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA003215
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PROGNOSTIC SUMMARY

Prognostic marker in head and neck cancer (unfavourable) and liver cancer (unfavourable).
Head and neck cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003215

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues displayed moderate to strong nuclear immunoreactivity. Strongest positivity was observed in testicular cancers.

GENE INFORMATION

Gene name

OGFOD1 (HGNC Symbol)

Synonyms

FLJ10826, KIAA1612, TPA1

Description

2-oxoglutarate and iron-dependent oxygenase domain containing 1 (HGNC Symbol)

Entrez gene summary

Chromosome

16

Cytoband

q13

Chromosome location (bp)

56451490 - 56479100

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087263 (version 83.38)

Entrez gene

55239

UniProt

Q8N543 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N543

Antibodypedia

OGFOD1 antibodies

PROTEIN BROWSER

OGFOD1-001
OGFOD1-003
OGFOD1-009
OGFOD1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OGFOD1-001
ENSP00000457258
ENST00000566157
Q8N543 [Direct mapping]
Prolyl 3-hydroxylase OGFOD1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006449 [regulation of translational termination]
GO:0008283 [cell proliferation]
GO:0010494 [cytoplasmic stress granule]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0018126 [protein hydroxylation]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0031418 [L-ascorbic acid binding]
GO:0031543 [peptidyl-proline dioxygenase activity]
GO:0031544 [peptidyl-proline 3-dioxygenase activity]
GO:0034063 [stress granule assembly]
GO:0055114 [oxidation-reduction process]
Show all
542 aa
63.2 kDa
No 0
OGFOD1-003
ENSP00000457746
ENST00000568397
A0A0A0MTR2 [Direct mapping]
Prolyl 3-hydroxylase OGFOD1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0031418 [L-ascorbic acid binding]
GO:0055114 [oxidation-reduction process]
Show all
499 aa
58.4 kDa
No 0
OGFOD1-009
ENSP00000457553
ENST00000561646
H3BUA6 [Direct mapping]
Prolyl 3-hydroxylase OGFOD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0031418 [L-ascorbic acid binding]
GO:0055114 [oxidation-reduction process]
Show all
175 aa
20.8 kDa
No 0
OGFOD1-011
ENSP00000456111
ENST00000562150
H3BR79 [Direct mapping]
Prolyl 3-hydroxylase OGFOD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
164 aa
19.2 kDa
No 0

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