Cell atlas - NID2 - The Human Protein Atlas

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NID2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	NID2
Gene description	Nidogen 2 (osteonidogen)
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (BJ, BJ hTERT+, ASC TERT1, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA052460 , HPA058772
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, ASC TERT1, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052460	BJ	Plasma membrane
	HPA052460	PC-3	Plasma membrane
	HPA052460	U-2 OS	Plasma membrane
	HPA058772	BJ	Plasma membrane

GENE INFORMATION
Gene name	NID2
Synonyms
Description	Nidogen 2 (osteonidogen) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
Chromosome	14
Cytoband	q22.1
Chromosome location (bp)	52004803 - 52069228
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087303 (version 83.38)
Entrez gene	22795
UniProt	Q14112 (UniProt - Evidence at protein level)
neXtProt	NX_Q14112
Antibodypedia	NID2 antibodies

PROTEIN BROWSER

NID2-001	NID2-004	NID2-201	NID2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NID2-001 ENSP00000216286 ENST00000216286	Q14112 [Direct mapping] Nidogen-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] GO:0071711 [basement membrane organization] Show all	1375 aa 151.3 kDa	Yes	0
NID2-004 ENSP00000452190 ENST00000556572	H0YJV3 [Direct mapping] Nidogen-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	644 aa 71.8 kDa	No	0
NID2-201 ENSP00000443730 ENST00000541773	A0A0A0MTL9 [Direct mapping] Nidogen-2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007160 [cell-matrix adhesion] Show all	1373 aa 150.5 kDa	Yes	0
NID2-202 ENSP00000482803 ENST00000617139	A0A087WZP6 [Direct mapping] Nidogen-2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	969 aa 107 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.