Expression of NID2 in cancer - Summary - The Human Protein Atlas

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NID2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NID2
Gene description	Nidogen 2 (osteonidogen)
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22, ASC TERT1, BJ, BJ hTERT+)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in connective tissue, most abundant in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA052460
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and stomach cancer (unfavourable).
Urothelial cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052460

GENE INFORMATION
Gene name	NID2
Synonyms
Description	Nidogen 2 (osteonidogen) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
Chromosome	14
Cytoband	q22.1
Chromosome location (bp)	52004803 - 52069228
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087303 (version 83.38)
Entrez gene	22795
UniProt	Q14112 (UniProt - Evidence at protein level)
neXtProt	NX_Q14112
Antibodypedia	NID2 antibodies

PROTEIN BROWSER

NID2-001	NID2-004	NID2-201	NID2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NID2-001 ENSP00000216286 ENST00000216286	Q14112 [Direct mapping] Nidogen-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] GO:0071711 [basement membrane organization] Show all	1375 aa 151.3 kDa	Yes	0
NID2-004 ENSP00000452190 ENST00000556572	H0YJV3 [Direct mapping] Nidogen-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	644 aa 71.8 kDa	No	0
NID2-201 ENSP00000443730 ENST00000541773	A0A0A0MTL9 [Direct mapping] Nidogen-2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007160 [cell-matrix adhesion] Show all	1373 aa 150.5 kDa	Yes	0
NID2-202 ENSP00000482803 ENST00000617139	A0A087WZP6 [Direct mapping] Nidogen-2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	969 aa 107 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.