Expression of SF3B2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SF3B2

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SF3B2
Gene description	Splicing factor 3b, subunit 2, 145kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA045028
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045028

GENE INFORMATION
Gene name	SF3B2 (HGNC Symbol)
Synonyms	Cus1, SAP145, SF3b1, SF3b145
Description	Splicing factor 3b, subunit 2, 145kDa (HGNC Symbol)
Entrez gene summary	This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	66050729 - 66069308
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087365 (version 83.38)
Entrez gene	10992
UniProt	Q13435 (UniProt - Evidence at protein level)
neXtProt	NX_Q13435
Antibodypedia	SF3B2 antibodies

PROTEIN BROWSER

SF3B2-001	SF3B2-006	SF3B2-009	SF3B2-012	SF3B2-015	SF3B2-018	SF3B2-019	SF3B2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SF3B2-001 ENSP00000318861 ENST00000322535	Q13435 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005684 [U2-type spliceosomal complex] GO:0005686 [U2 snRNP] GO:0005689 [U12-type spliceosomal complex] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0044822 [poly(A) RNA binding] GO:0071011 [precatalytic spliceosome] GO:0071013 [catalytic step 2 spliceosome] Show all	895 aa 100.2 kDa	No	0
SF3B2-006 ENSP00000432655 ENST00000528302	E9PPJ0 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	878 aa 98.2 kDa	No	0
SF3B2-009 ENSP00000435765 ENST00000524475	E9PIL8 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.5 kDa	No	0
SF3B2-012 ENSP00000431908 ENST00000533595	E9PJ04 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		354 aa 38.6 kDa	No	0
SF3B2-015 ENSP00000436757 ENST00000530981	H0YEX5 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		315 aa 34.9 kDa	No	0
SF3B2-018 ENSP00000431520 ENST00000530322	H0YCG1 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		387 aa 42.5 kDa	No	0
SF3B2-019 ENSP00000435495 ENST00000524627	E9PJT3 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		273 aa 29.1 kDa	No	0
SF3B2-201 ENSP00000482986 ENST00000610523	A0A087WZZ5 [Direct mapping] Splicing factor 3B subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	871 aa 97.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.