Fields »
ABOUT
HELP
BLOG
SF3B2

GENERAL INFORMATION

Gene name

 SF3B2

Gene description

 Splicing factor 3b, subunit 2, 145kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA045028
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SF3B2 (HGNC Symbol)

Synonyms

 Cus1, SAP145, SF3b1, SF3b145

Description

 Splicing factor 3b, subunit 2, 145kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 66050729 - 66069308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087365 (version 83.38)

Entrez gene

 10992

UniProt

 Q13435 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13435

Antibodypedia

 SF3B2 antibodies

PROTEIN BROWSER
SF3B2-001
SF3B2-006
SF3B2-009
SF3B2-012
SF3B2-015
SF3B2-018
SF3B2-019
SF3B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SF3B2-001
ENSP00000318861
ENST00000322535
Q13435 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005684 [U2-type spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0044822 [poly(A) RNA binding]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 895 aa
100.2 kDa 		No 0
SF3B2-006
ENSP00000432655
ENST00000528302
E9PPJ0 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
Show all
 878 aa
98.2 kDa 		No 0
SF3B2-009
ENSP00000435765
ENST00000524475
E9PIL8 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 81 aa
8.5 kDa 		No 0
SF3B2-012
ENSP00000431908
ENST00000533595
E9PJ04 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 354 aa
38.6 kDa 		No 0
SF3B2-015
ENSP00000436757
ENST00000530981
H0YEX5 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 315 aa
34.9 kDa 		No 0
SF3B2-018
ENSP00000431520
ENST00000530322
H0YCG1 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 387 aa
42.5 kDa 		No 0
SF3B2-019
ENSP00000435495
ENST00000524627
E9PJT3 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 273 aa
29.1 kDa 		No 0
SF3B2-201
ENSP00000482986
ENST00000610523
A0A087WZZ5 [Direct mapping]
Splicing factor 3B subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
 871 aa
97.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.