Cell atlas - PTHLH - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PTHLH

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleoplasm

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PTHLH
Gene description	Parathyroid hormone-like hormone
Protein class	Cancer-related genes Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the Golgi apparatus.
RNA cell category	Group enriched (HaCaT, U-251 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Cytosol (supported)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA035982
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HaCaT, U-251 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the Golgi apparatus.

Main location

Nucleoplasm (supported), Cytosol (supported)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035982	A-431	Nucleoplasm
	HPA035982	A-431	Cytosol
	HPA035982	U-2 OS	Nucleoplasm
	HPA035982	U-2 OS	Cytosol
	HPA035982	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	PTHLH (HGNC Symbol)
Synonyms	HHM, PLP, PTHR, PTHRP
Description	Parathyroid hormone-like hormone (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
Chromosome	12
Cytoband	p11.22
Chromosome location (bp)	27958084 - 27972705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087494 (version 83.38)
Entrez gene	5744
UniProt	P12272 (UniProt - Evidence at protein level)
neXtProt	NX_P12272
Antibodypedia	PTHLH antibodies

PROTEIN BROWSER

PTHLH-001	PTHLH-002	PTHLH-003	PTHLH-004	PTHLH-006	PTHLH-007	PTHLH-008	PTHLH-201	PTHLH-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTHLH-001 ENSP00000441765 ENST00000545234	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin A0A024RB29 [Target identity:100%; Query identity:100%] Parathyroid hormone-like hormone, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0001958 [endochondral ossification] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007492 [endoderm development] GO:0007565 [female pregnancy] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0016485 [protein processing] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0030855 [epithelial cell differentiation] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0043129 [surfactant homeostasis] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0046058 [cAMP metabolic process] GO:0048286 [lung alveolus development] GO:0051428 [peptide hormone receptor binding] GO:0060649 [mammary gland bud elongation] GO:0060659 [nipple sheath formation] Show all	177 aa 20.2 kDa	Yes	0
PTHLH-002 ENSP00000379209 ENST00000395868	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin Q53XY9 [Target identity:100%; Query identity:100%] Parathyroid hormone-like hormone; Parathyroid hormone-like hormone, isoform CRA_a; cDNA, FLJ94023, Homo sapiens parathyroid hormone-like hormone (PTHLH), mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0046058 [cAMP metabolic process] GO:0051428 [peptide hormone receptor binding] Show all	175 aa 19.9 kDa	Yes	0
PTHLH-003 ENSP00000440613 ENST00000535992	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin Q53XY9 [Target identity:100%; Query identity:100%] Parathyroid hormone-like hormone; Parathyroid hormone-like hormone, isoform CRA_a; cDNA, FLJ94023, Homo sapiens parathyroid hormone-like hormone (PTHLH), mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0046058 [cAMP metabolic process] GO:0051428 [peptide hormone receptor binding] Show all	175 aa 19.9 kDa	Yes	0
PTHLH-004 ENSP00000441890 ENST00000538310	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0046058 [cAMP metabolic process] GO:0051428 [peptide hormone receptor binding] Show all	209 aa 23.9 kDa	Yes	0
PTHLH-006 ENSP00000445157 ENST00000534890	F5H485 [Direct mapping] Parathyroid hormone-related protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0032330 [regulation of chondrocyte differentiation] Show all	111 aa 12.7 kDa	Yes	0
PTHLH-007 ENSP00000444519 ENST00000542963	F5GZD9 [Direct mapping] Parathyroid hormone-related protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0032330 [regulation of chondrocyte differentiation] Show all	172 aa 19.5 kDa	Yes	0
PTHLH-008 ENSP00000441571 ENST00000539239	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin A0A024RB29 [Target identity:100%; Query identity:100%] Parathyroid hormone-like hormone, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0046058 [cAMP metabolic process] GO:0051428 [peptide hormone receptor binding] Show all	177 aa 20.2 kDa	Yes	0
PTHLH-201 ENSP00000201015 ENST00000201015	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin Q53XY9 [Target identity:100%; Query identity:100%] Parathyroid hormone-like hormone; Parathyroid hormone-like hormone, isoform CRA_a; cDNA, FLJ94023, Homo sapiens parathyroid hormone-like hormone (PTHLH), mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0046058 [cAMP metabolic process] GO:0051428 [peptide hormone receptor binding] Show all	175 aa 19.9 kDa	Yes	0
PTHLH-202 ENSP00000379213 ENST00000395872	P12272 [Direct mapping] Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin A0A024RB29 [Target identity:100%; Query identity:100%] Parathyroid hormone-like hormone, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0001501 [skeletal system development] GO:0002076 [osteoblast development] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007565 [female pregnancy] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0010468 [regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0046058 [cAMP metabolic process] GO:0051428 [peptide hormone receptor binding] Show all	177 aa 20.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.