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PTHLH

GENERAL INFORMATION

Gene name

 PTHLH

Gene description

 Parathyroid hormone-like hormone

Protein class

 Cancer-related genes
Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Group enriched (HaCaT, U-251 MG)
HPA (normal tissue):Tissue enhanced (breast)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues, including mammary glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035982
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035982

GENE INFORMATION

Gene name

 PTHLH (HGNC Symbol)

Synonyms

 HHM, PLP, PTHR, PTHRP

Description

 Parathyroid hormone-like hormone (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]

Chromosome

 12

Cytoband

 p11.22

Chromosome location (bp)

 27958084 - 27972705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087494 (version 83.38)

Entrez gene

 5744

UniProt

 P12272 (UniProt - Evidence at protein level)

neXtProt

 NX_P12272

Antibodypedia

 PTHLH antibodies

PROTEIN BROWSER
PTHLH-001
PTHLH-002
PTHLH-003
PTHLH-004
PTHLH-006
PTHLH-007
PTHLH-008
PTHLH-201
PTHLH-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTHLH-001
ENSP00000441765
ENST00000545234
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
A0A024RB29 [Target identity:100%; Query identity:100%]
Parathyroid hormone-like hormone, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0001958 [endochondral ossification]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007492 [endoderm development]
GO:0007565 [female pregnancy]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0016485 [protein processing]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0030855 [epithelial cell differentiation]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0043129 [surfactant homeostasis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0046058 [cAMP metabolic process]
GO:0048286 [lung alveolus development]
GO:0051428 [peptide hormone receptor binding]
GO:0060649 [mammary gland bud elongation]
GO:0060659 [nipple sheath formation]
Show all
 177 aa
20.2 kDa 		Yes 0
PTHLH-002
ENSP00000379209
ENST00000395868
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
Q53XY9 [Target identity:100%; Query identity:100%]
Parathyroid hormone-like hormone; Parathyroid hormone-like hormone, isoform CRA_a; cDNA, FLJ94023, Homo sapiens parathyroid hormone-like hormone (PTHLH), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0046058 [cAMP metabolic process]
GO:0051428 [peptide hormone receptor binding]
Show all
 175 aa
19.9 kDa 		Yes 0
PTHLH-003
ENSP00000440613
ENST00000535992
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
Q53XY9 [Target identity:100%; Query identity:100%]
Parathyroid hormone-like hormone; Parathyroid hormone-like hormone, isoform CRA_a; cDNA, FLJ94023, Homo sapiens parathyroid hormone-like hormone (PTHLH), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0046058 [cAMP metabolic process]
GO:0051428 [peptide hormone receptor binding]
Show all
 175 aa
19.9 kDa 		Yes 0
PTHLH-004
ENSP00000441890
ENST00000538310
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0046058 [cAMP metabolic process]
GO:0051428 [peptide hormone receptor binding]
Show all
 209 aa
23.9 kDa 		Yes 0
PTHLH-006
ENSP00000445157
ENST00000534890
F5H485 [Direct mapping]
Parathyroid hormone-related protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0032330 [regulation of chondrocyte differentiation]
Show all
 111 aa
12.7 kDa 		Yes 0
PTHLH-007
ENSP00000444519
ENST00000542963
F5GZD9 [Direct mapping]
Parathyroid hormone-related protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0032330 [regulation of chondrocyte differentiation]
Show all
 172 aa
19.5 kDa 		Yes 0
PTHLH-008
ENSP00000441571
ENST00000539239
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
A0A024RB29 [Target identity:100%; Query identity:100%]
Parathyroid hormone-like hormone, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0046058 [cAMP metabolic process]
GO:0051428 [peptide hormone receptor binding]
Show all
 177 aa
20.2 kDa 		Yes 0
PTHLH-201
ENSP00000201015
ENST00000201015
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
Q53XY9 [Target identity:100%; Query identity:100%]
Parathyroid hormone-like hormone; Parathyroid hormone-like hormone, isoform CRA_a; cDNA, FLJ94023, Homo sapiens parathyroid hormone-like hormone (PTHLH), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0046058 [cAMP metabolic process]
GO:0051428 [peptide hormone receptor binding]
Show all
 175 aa
19.9 kDa 		Yes 0
PTHLH-202
ENSP00000379213
ENST00000395872
P12272 [Direct mapping]
Parathyroid hormone-related protein PTHrP[1-36] PTHrP[38-94] Osteostatin
A0A024RB29 [Target identity:100%; Query identity:100%]
Parathyroid hormone-like hormone, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001501 [skeletal system development]
GO:0002076 [osteoblast development]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0008285 [negative regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010468 [regulation of gene expression]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0046058 [cAMP metabolic process]
GO:0051428 [peptide hormone receptor binding]
Show all
 177 aa
20.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.