Expression of AAMDC in cancer - Summary

GENERAL INFORMATION
Gene name	AAMDC
Gene description	Adipogenesis associated, Mth938 domain containing
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells including Leydig cells, Purkinje cells and cells in the gastric mucosa.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA037918 , HPA037919
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA037918	HPA037919

GENE INFORMATION
Gene name	AAMDC (HGNC Symbol)
Synonyms	C11orf67, CK067, FLJ21035, PTD015
Description	Adipogenesis associated, Mth938 domain containing (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q14.1
Chromosome location (bp)	77821109 - 77918432
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087884 (version 83.38)
Entrez gene	28971
UniProt	Q9H7C9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H7C9
Antibodypedia	AAMDC antibodies

PROTEIN BROWSER

AAMDC-001	AAMDC-002	AAMDC-003	AAMDC-005	AAMDC-007	AAMDC-008	AAMDC-009	AAMDC-010	AAMDC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AAMDC-001 ENSP00000377078 ENST00000393427	Q9H7C9 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	122 aa 13.3 kDa	No	0
AAMDC-002 ENSP00000307254 ENST00000304716	K4DI89 [Direct mapping] Mth938 domain-containing protein; PTD015 protein, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	147 aa 16.4 kDa	No	0
AAMDC-003 ENSP00000433293 ENST00000532481	Q9H7C9 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	88 aa 9.6 kDa	No	0
AAMDC-005 ENSP00000431808 ENST00000526415	Q9H7C9 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	122 aa 13.3 kDa	No	0
AAMDC-007 ENSP00000436086 ENST00000533193	E9PR47 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	168 aa 17.9 kDa	No	0
AAMDC-008 ENSP00000433956 ENST00000525409	E9PIQ4 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	90 aa 10 kDa	No	0
AAMDC-009 ENSP00000433281 ENST00000527134	E9PLK9 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	137 aa 15.2 kDa	No	0
AAMDC-010 ENSP00000432830 ENST00000525034	E9PNP3 [Direct mapping] Mth938 domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	141 aa 15.6 kDa	No	0
AAMDC-201 ENSP00000486080 ENST00000630098	K4DI89 [Direct mapping] Mth938 domain-containing protein; PTD015 protein, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043066 [negative regulation of apoptotic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	147 aa 16.4 kDa	No	0