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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AAMDC
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AAMDC

Gene description

Adipogenesis associated, Mth938 domain containing

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells including Leydig cells, Purkinje cells and cells in the gastric mucosa.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA037918 , HPA037919
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY

HPA037918
HPA037919

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of ductal breast carcinomas exhibited strong cytoplasmic positivity. Several carcinoids, ovarian, prostate, pancreatic and thyroid cancers as well as a few melanomas, colorectal, lung and urothelial cancers showed moderate staining. Cancer cells in general were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several prostate and ovarian cancers along with a few cases of duct carcinomas of breast displayed moderate to strong cytoplasmic immunoreactivity. Remaining cancer cells were generally negative.

GENE INFORMATION

Gene name

AAMDC (HGNC Symbol)

Synonyms

C11orf67, CK067, FLJ21035, PTD015

Description

Adipogenesis associated, Mth938 domain containing (HGNC Symbol)

Entrez gene summary

Chromosome

11

Cytoband

q14.1

Chromosome location (bp)

77821109 - 77918432

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087884 (version 83.38)

Entrez gene

28971

UniProt

Q9H7C9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H7C9

Antibodypedia

AAMDC antibodies

PROTEIN BROWSER

AAMDC-001
AAMDC-002
AAMDC-003
AAMDC-005
AAMDC-007
AAMDC-008
AAMDC-009
AAMDC-010
AAMDC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AAMDC-001
ENSP00000377078
ENST00000393427
Q9H7C9 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
122 aa
13.3 kDa
No 0
AAMDC-002
ENSP00000307254
ENST00000304716
K4DI89 [Direct mapping]
Mth938 domain-containing protein; PTD015 protein, isoform CRA_c
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
147 aa
16.4 kDa
No 0
AAMDC-003
ENSP00000433293
ENST00000532481
Q9H7C9 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
88 aa
9.6 kDa
No 0
AAMDC-005
ENSP00000431808
ENST00000526415
Q9H7C9 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
122 aa
13.3 kDa
No 0
AAMDC-007
ENSP00000436086
ENST00000533193
E9PR47 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
168 aa
17.9 kDa
No 0
AAMDC-008
ENSP00000433956
ENST00000525409
E9PIQ4 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
90 aa
10 kDa
No 0
AAMDC-009
ENSP00000433281
ENST00000527134
E9PLK9 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
137 aa
15.2 kDa
No 0
AAMDC-010
ENSP00000432830
ENST00000525034
E9PNP3 [Direct mapping]
Mth938 domain-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
141 aa
15.6 kDa
No 0
AAMDC-201
ENSP00000486080
ENST00000630098
K4DI89 [Direct mapping]
Mth938 domain-containing protein; PTD015 protein, isoform CRA_c
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043066 [negative regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
147 aa
16.4 kDa
No 0

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