Tissue expression of CNOT3 - Summary - The Human Protein Atlas

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CNOT3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CNOT3
Gene description	CCR4-NOT transcription complex, subunit 3
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA006408
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

N/A

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CNOT3 (HGNC Symbol)
Synonyms	KIAA0691, LENG2, NOT3, NOT3H
Description	CCR4-NOT transcription complex, subunit 3 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54137728 - 54155681
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088038 (version 83.38)
Entrez gene	4849
UniProt	O75175 (UniProt - Evidence at protein level)
neXtProt	NX_O75175
Antibodypedia	CNOT3 antibodies

PROTEIN BROWSER

CNOT3-001	CNOT3-003	CNOT3-006	CNOT3-009	CNOT3-011	CNOT3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNOT3-001 ENSP00000221232 ENST00000221232	O75175 [Direct mapping] CCR4-NOT transcription complex subunit 3 A0A024R4R3 [Target identity:100%; Query identity:100%] CCR4-NOT transcription complex, subunit 3, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932 [cytoplasmic mRNA processing body] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010467 [gene expression] GO:0017148 [negative regulation of translation] GO:0030014 [CCR4-NOT complex] GO:0030015 [CCR4-NOT core complex] GO:0031047 [gene silencing by RNA] GO:2000036 [regulation of stem cell population maintenance] Show all	753 aa 81.9 kDa	No	0
CNOT3-003 ENSP00000351159 ENST00000358389	O75175 [Direct mapping] CCR4-NOT transcription complex subunit 3 A0A024R4R3 [Target identity:100%; Query identity:100%] CCR4-NOT transcription complex, subunit 3, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932 [cytoplasmic mRNA processing body] GO:0001829 [trophectodermal cell differentiation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010467 [gene expression] GO:0017148 [negative regulation of translation] GO:0030014 [CCR4-NOT complex] GO:0030015 [CCR4-NOT core complex] GO:0031047 [gene silencing by RNA] GO:2000036 [regulation of stem cell population maintenance] Show all	753 aa 81.9 kDa	No	0
CNOT3-006 ENSP00000401703 ENST00000457463	H0Y5X7 [Direct mapping] CCR4-NOT transcription complex subunit 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	288 aa 31.2 kDa	No	0
CNOT3-009 ENSP00000398463 ENST00000440571	H7C148 [Direct mapping] CCR4-NOT transcription complex subunit 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	375 aa 39.4 kDa	No	0
CNOT3-011 ENSP00000420064 ENST00000471126	H7C5J4 [Direct mapping] CCR4-NOT transcription complex subunit 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	88 aa 10.8 kDa	No	0
CNOT3-201 ENSP00000411587 ENST00000447684	H7C3F5 [Direct mapping] CCR4-NOT transcription complex subunit 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	571 aa 58.9 kDa	No	0

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