Expression of DDX18 in cancer - Summary - The Human Protein Atlas

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DDX18

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DDX18
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA035400
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and liver cancer (unfavourable).
Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035400

GENE INFORMATION
Gene name	DDX18 (HGNC Symbol)
Synonyms	MrDb
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	117814650 - 117832379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088205 (version 83.38)
Entrez gene	8886
UniProt	Q9NVP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVP1
Antibodypedia	DDX18 antibodies

PROTEIN BROWSER

DDX18-001	DDX18-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX18-001 ENSP00000263239 ENST00000263239	Q9NVP1 [Direct mapping] ATP-dependent RNA helicase DDX18 A0A024RAH8 [Target identity:100%; Query identity:100%] DEAD (Asp-Glu-Ala-Asp) box polypeptide 18, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	670 aa 75.4 kDa	No	0
DDX18-003 ENSP00000415604 ENST00000415038	H7C452 [Direct mapping] ATP-dependent RNA helicase DDX18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	214 aa 24.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.