Expression of ASAP3 in cancer - Summary - The Human Protein Atlas

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ASAP3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASAP3
Gene description	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BEWO)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of leukocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA020537 , HPA020546
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable), endometrial cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Endometrial cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020537	HPA020546

GENE INFORMATION
Gene name	ASAP3 (HGNC Symbol)
Synonyms	CENTB6, DDEFL1, FLJ20199, UPLC1
Description	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	23428563 - 23484568
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088280 (version 83.38)
Entrez gene	55616
UniProt	Q8TDY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDY4
Antibodypedia	ASAP3 antibodies

PROTEIN BROWSER

ASAP3-001	ASAP3-005	ASAP3-006	ASAP3-011	ASAP3-014	ASAP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASAP3-001 ENSP00000338769 ENST00000336689	Q8TDY4 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 A0A024RAB1 [Target identity:100%; Query identity:100%] Development and differentiation enhancing factor-like 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0016477 [cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051492 [regulation of stress fiber assembly] Show all	903 aa 99.2 kDa	No	0
ASAP3-005 ENSP00000436150 ENST00000495646	Q8TDY4 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0016477 [cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051492 [regulation of stress fiber assembly] Show all	407 aa 43.7 kDa	No	0
ASAP3-006 ENSP00000435394 ENST00000465372	H0YEB0 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 21.6 kDa	No	0
ASAP3-011 ENSP00000408826 ENST00000437606	Q8TDY4 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0016477 [cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051492 [regulation of stress fiber assembly] Show all	894 aa 97.8 kDa	No	0
ASAP3-014 ENSP00000476400 ENST00000608765	V9GY49 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.4 kDa	No	0
ASAP3-201 ENSP00000483740 ENST00000618240	A0A087X0Y5 [Direct mapping] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		202 aa 22.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.