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ASAP3

GENERAL INFORMATION

Gene name

 ASAP3

Gene description

 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of leukocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA020537 , HPA020546
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ASAP3 (HGNC Symbol)

Synonyms

 CENTB6, DDEFL1, FLJ20199, UPLC1

Description

 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 23428563 - 23484568

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088280 (version 83.38)

Entrez gene

 55616

UniProt

 Q8TDY4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDY4

Antibodypedia

 ASAP3 antibodies

PROTEIN BROWSER
ASAP3-001
ASAP3-005
ASAP3-006
ASAP3-011
ASAP3-014
ASAP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASAP3-001
ENSP00000338769
ENST00000336689
Q8TDY4 [Direct mapping]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
A0A024RAB1 [Target identity:100%; Query identity:100%]
Development and differentiation enhancing factor-like 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0016477 [cell migration]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051492 [regulation of stress fiber assembly]
Show all
 903 aa
99.2 kDa 		No 0
ASAP3-005
ENSP00000436150
ENST00000495646
Q8TDY4 [Direct mapping]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0016477 [cell migration]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051492 [regulation of stress fiber assembly]
Show all
 407 aa
43.7 kDa 		No 0
ASAP3-006
ENSP00000435394
ENST00000465372
H0YEB0 [Direct mapping]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 203 aa
21.6 kDa 		No 0
ASAP3-011
ENSP00000408826
ENST00000437606
Q8TDY4 [Direct mapping]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0016477 [cell migration]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051492 [regulation of stress fiber assembly]
Show all
 894 aa
97.8 kDa 		No 0
ASAP3-014
ENSP00000476400
ENST00000608765
V9GY49 [Direct mapping]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 157 aa
17.4 kDa 		No 0
ASAP3-201
ENSP00000483740
ENST00000618240
A0A087X0Y5 [Direct mapping]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 202 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.