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TPX2

GENERAL INFORMATION

Gene name

 TPX2

Gene description

 TPX2, microtubule-associated

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear or cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA005487
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), endometrial cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005487

GENE INFORMATION

Gene name

 TPX2 (HGNC Symbol)

Synonyms

 C20orf1, C20orf2, DIL-2, p100

Description

 TPX2, microtubule-associated (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31739271 - 31801805

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088325 (version 83.38)

Entrez gene

 22974

UniProt

 Q9ULW0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULW0

Antibodypedia

 TPX2 antibodies

PROTEIN BROWSER
TPX2-001
TPX2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPX2-001
ENSP00000300403
ENST00000300403
Q9ULW0 [Direct mapping]
Targeting protein for Xklp2
Q643R0 [Target identity:100%; Query identity:100%]
HCTP4; TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_b; cDNA, FLJ92922
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0043203 [axon hillock]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061676 [importin-alpha family protein binding]
GO:0090307 [mitotic spindle assembly]
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 747 aa
85.7 kDa 		No 0
TPX2-002
ENSP00000341145
ENST00000340513
Q9ULW0 [Direct mapping]
Targeting protein for Xklp2
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019901 [protein kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0061676 [importin-alpha family protein binding]
GO:0090307 [mitotic spindle assembly]
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 783 aa
89.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.