Cell atlas - PPP1R13B - The Human Protein Atlas

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PPP1R13B

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PPP1R13B
Gene description	Protein phosphatase 1, regulatory subunit 13B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006394
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006394	A-431	Nucleoplasm
	HPA006394	A-431	Cytosol
	HPA006394	U-2 OS	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA006394	U-251 MG	Nucleoplasm
	HPA006394	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PPP1R13B (HGNC Symbol)
Synonyms	ASPP1, KIAA0771, p53BP2-like, p85
Description	Protein phosphatase 1, regulatory subunit 13B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	103733752 - 103847590
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088808 (version 83.38)
Entrez gene	23368
UniProt	Q96KQ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KQ4
Antibodypedia	PPP1R13B antibodies

PROTEIN BROWSER

PPP1R13B-001	PPP1R13B-009	PPP1R13B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R13B-001 ENSP00000202556 ENST00000202556	Q96KQ4 [Direct mapping] Apoptosis-stimulating of p53 protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008134 [transcription factor binding] GO:0045786 [negative regulation of cell cycle] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	1090 aa 119.6 kDa	No	0
PPP1R13B-009 ENSP00000452376 ENST00000555734	G3V5J1 [Direct mapping] Apoptosis-stimulating of p53 protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0008134 [transcription factor binding] GO:0045786 [negative regulation of cell cycle] Show all	149 aa 17.3 kDa	No	0
PPP1R13B-010 ENSP00000450734 ENST00000553739	G3V2L3 [Direct mapping] Apoptosis-stimulating of p53 protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0008134 [transcription factor binding] GO:0045786 [negative regulation of cell cycle] Show all	144 aa 16.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.