Expression of PPP1R13B in cancer - Summary - The Human Protein Atlas

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PPP1R13B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPP1R13B
Gene description	Protein phosphatase 1, regulatory subunit 13B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA006394 , CAB015454
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006394	CAB015454

GENE INFORMATION
Gene name	PPP1R13B (HGNC Symbol)
Synonyms	ASPP1, KIAA0771, p53BP2-like, p85
Description	Protein phosphatase 1, regulatory subunit 13B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	103733752 - 103847590
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088808 (version 83.38)
Entrez gene	23368
UniProt	Q96KQ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KQ4
Antibodypedia	PPP1R13B antibodies

PROTEIN BROWSER

PPP1R13B-001	PPP1R13B-009	PPP1R13B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R13B-001 ENSP00000202556 ENST00000202556	Q96KQ4 [Direct mapping] Apoptosis-stimulating of p53 protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008134 [transcription factor binding] GO:0045786 [negative regulation of cell cycle] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	1090 aa 119.6 kDa	No	0
PPP1R13B-009 ENSP00000452376 ENST00000555734	G3V5J1 [Direct mapping] Apoptosis-stimulating of p53 protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0008134 [transcription factor binding] GO:0045786 [negative regulation of cell cycle] Show all	149 aa 17.3 kDa	No	0
PPP1R13B-010 ENSP00000450734 ENST00000553739	G3V2L3 [Direct mapping] Apoptosis-stimulating of p53 protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0008134 [transcription factor binding] GO:0045786 [negative regulation of cell cycle] Show all	144 aa 16.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.