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MAPKAPK5

GENERAL INFORMATION

Gene name

 MAPKAPK5

Gene description

 Mitogen-activated protein kinase-activated protein kinase 5

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA015515 , CAB004546
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015515
CAB004546

GENE INFORMATION

Gene name

 MAPKAPK5 (HGNC Symbol)

Synonyms

 PRAK

Description

 Mitogen-activated protein kinase-activated protein kinase 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

Chromosome

 12

Cytoband

Chromosome location (bp)

 111841978 - 111902238

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089022 (version 83.38)

Entrez gene

 8550

UniProt

 Q8IW41 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IW41

Antibodypedia

 MAPKAPK5 antibodies

PROTEIN BROWSER
MAPKAPK5-001
MAPKAPK5-002
MAPKAPK5-003
MAPKAPK5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPKAPK5-001
ENSP00000449667
ENST00000550735
Q8IW41 [Direct mapping]
MAP kinase-activated protein kinase 5
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002039 [p53 binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032007 [negative regulation of TOR signaling]
GO:0046777 [protein autophosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0090400 [stress-induced premature senescence]
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 471 aa
54 kDa 		No 1
MAPKAPK5-002
ENSP00000449381
ENST00000551404
Q8IW41 [Direct mapping]
MAP kinase-activated protein kinase 5
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002039 [p53 binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032007 [negative regulation of TOR signaling]
GO:0046777 [protein autophosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0090400 [stress-induced premature senescence]
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 473 aa
54.2 kDa 		No 1
MAPKAPK5-003
ENSP00000473541
ENST00000547305
R4GN93 [Direct mapping]
MAP kinase-activated protein kinase 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004871 [signal transducer activity]
GO:0005516 [calmodulin binding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032007 [negative regulation of TOR signaling]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 51 aa
5.9 kDa 		No 0
MAPKAPK5-005
ENSP00000473467
ENST00000549875
R4GN33 [Direct mapping]
MAP kinase-activated protein kinase 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004871 [signal transducer activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032007 [negative regulation of TOR signaling]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 324 aa
37.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.