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Melanomas exhibited moderate to strong membranous and cytoplasmic positivity. Weak to moderate cytoplasmic and occasional membranous positivity was observed in breast, prostate, gastric cancer along with several colorectal, ovarian, skin and pancreatic cancers. Other malignancies were mainly negative.
Many papillary adenocarcinomas of thyroid along with a few hepatocellular carcinomas, melanomas, lung and ovarian cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
Majority of the cancers tissues exhibited weak to moderate cytoplasmic immunoreactivity, often seen with a granular pattern.
GENE INFORMATION
Gene name
P2RX7 (HGNC Symbol)
Synonyms
MGC20089, P2X7
Description
Purinergic receptor P2X, ligand gated ion channel, 7 (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]