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GCN1

GENERAL INFORMATION

Gene name

 GCN1

Gene description

 GCN1 eIF2 alpha kinase activator homolog

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA018799 , HPA019648 , HPA024367
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018799
HPA019648
HPA024367

GENE INFORMATION

Gene name

 GCN1 (HGNC Symbol)

Synonyms

 GCN1L, GCN1L1, KIAA0219

Description

 GCN1 eIF2 alpha kinase activator homolog (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q24.23

Chromosome location (bp)

 120127203 - 120194710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089154 (version 83.38)

Entrez gene

 10985

UniProt

 Q92616 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92616

Antibodypedia

 GCN1 antibodies

PROTEIN BROWSER
GCN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GCN1-001
ENSP00000300648
ENST00000300648
Q92616 [Direct mapping]
Translational activator GCN1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0005844 [polysome]
GO:0006412 [translation]
GO:0006417 [regulation of translation]
GO:0008135 [translation factor activity, RNA binding]
GO:0016020 [membrane]
GO:0034198 [cellular response to amino acid starvation]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0044822 [poly(A) RNA binding]
GO:1990253 [cellular response to leucine starvation]
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 2671 aa
292.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.