Expression of TRMT6 in cancer - Summary - The Human Protein Atlas

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TRMT6

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRMT6
Gene description	TRNA methyltransferase 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA047032
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047032

GENE INFORMATION
Gene name	TRMT6 (HGNC Symbol)
Synonyms	CGI-09, GCD10, Gcd10p, MGC5029
Description	TRNA methyltransferase 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	p12.3
Chromosome location (bp)	5937235 - 5950558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089195 (version 83.38)
Entrez gene	51605
UniProt	Q9UJA5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJA5
Antibodypedia	TRMT6 antibodies

PROTEIN BROWSER

TRMT6-001	TRMT6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRMT6-001 ENSP00000203001 ENST00000203001	Q9UJA5 [Direct mapping] tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0031515 [tRNA (m1A) methyltransferase complex] GO:0044822 [poly(A) RNA binding] Show all	497 aa 55.8 kDa	No	0
TRMT6-201 ENSP00000392070 ENST00000453074	Q9UJA5 [Direct mapping] tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0031515 [tRNA (m1A) methyltransferase complex] GO:0044822 [poly(A) RNA binding] Show all	327 aa 36.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.