Cell atlas - PEBP1 - The Human Protein Atlas

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PEBP1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PEBP1
Gene description	Phosphatidylethanolamine binding protein 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB009906
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB009906	A-431	Plasma membrane
	CAB009906	A-431	Cytosol
	CAB009906	U-2 OS	Plasma membrane
	CAB009906	U-2 OS	Cytosol
	CAB009906	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PEBP1 (HGNC Symbol)
Synonyms	HCNP, PBP, PEBP, RKIP
Description	Phosphatidylethanolamine binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
Chromosome	12
Cytoband	q24.23
Chromosome location (bp)	118135858 - 118145584
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089220 (version 83.38)
Entrez gene	5037
UniProt	P30086 (UniProt - Evidence at protein level)
neXtProt	NX_P30086
Antibodypedia	PEBP1 antibodies

PROTEIN BROWSER

PEBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEBP1-001 ENSP00000261313 ENST00000261313	P30086 [Direct mapping] Phosphatidylethanolamine-binding protein 1 Hippocampal cholinergic neurostimulating peptide D9IAI1 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 34; Phosphatidylethanolamine binding protein 1, isoform CRA_a; Phosphatidylethanolamine-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008429 [phosphatidylethanolamine binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010951 [negative regulation of endopeptidase activity] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	187 aa 21.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.