Expression of PEBP1 in cancer - Summary

GENERAL INFORMATION
Gene name	PEBP1
Gene description	Phosphatidylethanolamine binding protein 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a majority of tissues. Highest levels in endocrine tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA008819 , CAB013493
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA008819	CAB013493

GENE INFORMATION
Gene name	PEBP1 (HGNC Symbol)
Synonyms	HCNP, PBP, PEBP, RKIP
Description	Phosphatidylethanolamine binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
Chromosome	12
Cytoband	q24.23
Chromosome location (bp)	118135858 - 118145584
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089220 (version 83.38)
Entrez gene	5037
UniProt	P30086 (UniProt - Evidence at protein level)
neXtProt	NX_P30086
Antibodypedia	PEBP1 antibodies

PROTEIN BROWSER

PEBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEBP1-001 ENSP00000261313 ENST00000261313	P30086 [Direct mapping] Phosphatidylethanolamine-binding protein 1 Hippocampal cholinergic neurostimulating peptide D9IAI1 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 34; Phosphatidylethanolamine binding protein 1, isoform CRA_a; Phosphatidylethanolamine-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008429 [phosphatidylethanolamine binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010951 [negative regulation of endopeptidase activity] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	187 aa 21.1 kDa	No	0