Tissue expression of FXYD3 - Summary - The Human Protein Atlas

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FXYD3

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FXYD3
Gene description	FXYD domain containing ion transport regulator 3
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (colon, rectum)
GTEx:	Tissue enhanced (colon)
FANTOM5:	Tissue enhanced (salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Membranous and cytoplasmic expression in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA010856
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, rectum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland)

GENE INFORMATION
Gene name	FXYD3 (HGNC Symbol)
Synonyms	MAT-8, PLML
Description	FXYD domain containing ion transport regulator 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35115879 - 35124324
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089356 (version 83.38)
Entrez gene	5349
UniProt	Q14802 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14802
Antibodypedia	FXYD3 antibodies

PROTEIN BROWSER

FXYD3-001	FXYD3-002	FXYD3-003	FXYD3-004	FXYD3-005	FXYD3-007	FXYD3-008	FXYD3-009	FXYD3-010	FXYD3-011	FXYD3-012	FXYD3-201	FXYD3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FXYD3-001 ENSP00000474438 ENST00000604404	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	87 aa 9.3 kDa	Yes	1
FXYD3-002 ENSP00000389770 ENST00000435734	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	113 aa 12 kDa	Yes	1
FXYD3-003 ENSP00000474855 ENST00000605552	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006821 [chloride transport] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	61 aa 6.7 kDa	Yes	0
FXYD3-004 ENSP00000474622 ENST00000605677	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	96 aa 10.3 kDa	Yes	1
FXYD3-005 ENSP00000473929 ENST00000604255	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0050790 [regulation of catalytic activity] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	144 aa 15.2 kDa	No	2
FXYD3-007 ENSP00000474055 ENST00000603449	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006821 [chloride transport] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	61 aa 6.7 kDa	Yes	0
FXYD3-008 ENSP00000474514 ENST00000605550	S4R3M2 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	70 aa 7.6 kDa	Yes	1
FXYD3-009 ENSP00000475056 ENST00000604804	S4R445 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	116 aa 12.4 kDa	Yes	1
FXYD3-010 ENSP00000474526 ENST00000604621	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	87 aa 9.3 kDa	Yes	1
FXYD3-011 ENSP00000474223 ENST00000603524	S4R445 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	116 aa 12.4 kDa	Yes	1
FXYD3-012 ENSP00000474851 ENST00000603181	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	87 aa 9.3 kDa	Yes	1
FXYD3-201 ENSP00000339499 ENST00000344013	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	113 aa 12 kDa	Yes	1
FXYD3-202 ENSP00000328259 ENST00000346446	Q14802 [Direct mapping] FXYD domain-containing ion transport regulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	113 aa 12 kDa	Yes	1

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The Human Protein Atlas

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