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BIRC5

GENERAL INFORMATION

Gene name

 BIRC5

Gene description

 Baculoviral IAP repeat containing 5

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct nuclear expression in a fraction of cells in squamous epithelia, lymphoid tissues, gastrointestinal tract, testis and glandular cells of female genitalia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002830 , CAB004270
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA002830
CAB004270

GENE INFORMATION

Gene name

 BIRC5 (HGNC Symbol)

Synonyms

 API4, EPR-1, survivin

Description

 Baculoviral IAP repeat containing 5 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 78214186 - 78225636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089685 (version 83.38)

Entrez gene

 332

UniProt

 O15392 (UniProt - Evidence at protein level)

neXtProt

 NX_O15392

Antibodypedia

 BIRC5 antibodies

PROTEIN BROWSER
BIRC5-001
BIRC5-002
BIRC5-003
BIRC5-004
BIRC5-005
BIRC5-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BIRC5-001
ENSP00000324180
ENST00000350051
A0A0B4J1S3 [Direct mapping]
Baculoviral IAP repeat-containing protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0009966 [regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 142 aa
16.4 kDa 		No 0
BIRC5-002
ENSP00000364086
ENST00000374948
O15392 [Direct mapping]
Baculoviral IAP repeat-containing protein 5
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008536 [Ran GTPase binding]
GO:0009966 [regulation of signal transduction]
GO:0015631 [tubulin binding]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0030496 [midbody]
GO:0031021 [interphase microtubule organizing center]
GO:0031503 [protein complex localization]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031577 [spindle checkpoint]
GO:0032133 [chromosome passenger complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048037 [cofactor binding]
GO:0050897 [cobalt ion binding]
GO:0051087 [chaperone binding]
GO:0051301 [cell division]
GO:0051303 [establishment of chromosome localization]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 137 aa
15.6 kDa 		No 0
BIRC5-003
ENSP00000465868
ENST00000590449
O15392 [Direct mapping]
Baculoviral IAP repeat-containing protein 5
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008536 [Ran GTPase binding]
GO:0009966 [regulation of signal transduction]
GO:0015631 [tubulin binding]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0030496 [midbody]
GO:0031021 [interphase microtubule organizing center]
GO:0031503 [protein complex localization]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031577 [spindle checkpoint]
GO:0032133 [chromosome passenger complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048037 [cofactor binding]
GO:0050897 [cobalt ion binding]
GO:0051087 [chaperone binding]
GO:0051301 [cell division]
GO:0051303 [establishment of chromosome localization]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 74 aa
8.5 kDa 		No 0
BIRC5-004
ENSP00000301633
ENST00000301633
H3BLT4 [Direct mapping]
Baculoviral IAP repeat-containing protein 5
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0007346 [regulation of mitotic cell cycle]
GO:0009966 [regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 165 aa
18.6 kDa 		No 0
BIRC5-005
ENSP00000466617
ENST00000592734
O15392 [Direct mapping]
Baculoviral IAP repeat-containing protein 5
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000777 [condensed chromosome kinetochore]
GO:0000910 [cytokinesis]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008536 [Ran GTPase binding]
GO:0009966 [regulation of signal transduction]
GO:0015631 [tubulin binding]
GO:0016567 [protein ubiquitination]
GO:0019899 [enzyme binding]
GO:0030496 [midbody]
GO:0031021 [interphase microtubule organizing center]
GO:0031503 [protein complex localization]
GO:0031536 [positive regulation of exit from mitosis]
GO:0031577 [spindle checkpoint]
GO:0032133 [chromosome passenger complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048037 [cofactor binding]
GO:0050897 [cobalt ion binding]
GO:0051087 [chaperone binding]
GO:0051301 [cell division]
GO:0051303 [establishment of chromosome localization]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 78 aa
9 kDa 		No 0
BIRC5-010
ENSP00000466675
ENST00000587746
K7EMW2 [Direct mapping]
Baculoviral IAP repeat-containing protein 5
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0009966 [regulation of signal transduction]
GO:0016567 [protein ubiquitination]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 121 aa
13.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.