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BLVRB

GENERAL INFORMATION

Gene name

 BLVRB

Gene description

 Biliverdin reductase B

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, K-562)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041698 , HPA041937
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041698
HPA041937

GENE INFORMATION

Gene name

 BLVRB (HGNC Symbol)

Synonyms

 FLR, SDR43U1

Description

 Biliverdin reductase B (HGNC Symbol)

Entrez gene summary

 The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 40447789 - 40465840

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090013 (version 83.38)

Entrez gene

 645

UniProt

 P30043 (UniProt - Evidence at protein level)

neXtProt

 NX_P30043

Antibodypedia

 BLVRB antibodies

PROTEIN BROWSER
BLVRB-001
BLVRB-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BLVRB-001
ENSP00000263368
ENST00000263368
P30043 [Direct mapping]
Flavin reductase (NADPH)
V9HWI1 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 10
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004074 [biliverdin reductase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0042167 [heme catabolic process]
GO:0042602 [riboflavin reductase (NADPH) activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 206 aa
22.1 kDa 		No 0
BLVRB-003
ENSP00000471720
ENST00000595483
M0R192 [Direct mapping]
Flavin reductase (NADPH)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 163 aa
17.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.