Expression of FETUB in cancer - Summary - The Human Protein Atlas

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FETUB

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FETUB
Gene description	Fetuin B
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, highest expression in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. HPA035132
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035132

GENE INFORMATION
Gene name	FETUB
Synonyms
Description	Fetuin B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.3
Chromosome location (bp)	186635969 - 186653141
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090512 (version 83.38)
Entrez gene	26998
UniProt	Q9UGM5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGM5
Antibodypedia	FETUB antibodies

PROTEIN BROWSER

FETUB-001	FETUB-002	FETUB-004	FETUB-005	FETUB-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FETUB-001 ENSP00000265029 ENST00000265029	Q9UGM5 [Direct mapping] Fetuin-B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0008150 [biological_process] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	382 aa 42.1 kDa	Yes	0
FETUB-002 ENSP00000404288 ENST00000450521	Q9UGM5 [Direct mapping] Fetuin-B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0008150 [biological_process] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	382 aa 42.1 kDa	Yes	0
FETUB-004 ENSP00000371569 ENST00000382134	E9PG08 [Direct mapping] Fetuin-B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	317 aa 34.6 kDa	Yes	0
FETUB-005 ENSP00000371571 ENST00000382136	Q9UGM5 [Direct mapping] Fetuin-B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0008150 [biological_process] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	345 aa 37.8 kDa	Yes	0
FETUB-007 ENSP00000396581 ENST00000431018	C9JC68 [Direct mapping] Fetuin-B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	104 aa 11.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.