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RAB11FIP3

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GENERAL INFORMATION

Gene name

 RAB11FIP3

Gene description

 RAB11 family interacting protein 3 (class II)

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubule organizing center & vesicles. In addition localized to the cytokinetic bridge.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported), Microtubule organizing center (supported)

Additional location

 In addition localized to the Cytokinetic bridge (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA028631 , HPA030086
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubule organizing center & vesicles. In addition localized to the cytokinetic bridge.

Main location

 Vesicles (supported), Microtubule organizing center (supported)

Additional location

 Cytokinetic bridge (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA028631 A-431 Nucleoplasm
Vesicles
HPA028631 U-2 OS Vesicles
Cytokinetic bridge Intensity Intensity
Microtubule organizing center
HPA028631 U-251 MG Vesicles
HPA030086 A-431 Vesicles
Microtubule organizing center
HPA030086 U-2 OS Vesicles
Microtubule organizing center
HPA030086 U-251 MG Vesicles

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Cytokinetic bridge

GENE INFORMATION

Gene name

 RAB11FIP3 (HGNC Symbol)

Synonyms

 eferin, KIAA0665, Rab11-FIP3

Description

 RAB11 family interacting protein 3 (class II) (HGNC Symbol)

Entrez gene summary

 Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 425619 - 523011

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090565 (version 83.38)

Entrez gene

 9727

UniProt

 O75154 (UniProt - Evidence at protein level)

neXtProt

 NX_O75154

Antibodypedia

 RAB11FIP3 antibodies

PROTEIN BROWSER
RAB11FIP3-001
RAB11FIP3-002
RAB11FIP3-004
RAB11FIP3-009
RAB11FIP3-010
RAB11FIP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB11FIP3-001
ENSP00000262305
ENST00000262305
O75154 [Direct mapping]
Rab11 family-interacting protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0030139 [endocytic vesicle]
GO:0030306 [ADP-ribosylation factor binding]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032456 [endocytic recycling]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0070164 [negative regulation of adiponectin secretion]
Show all
 756 aa
82.4 kDa 		No 0
RAB11FIP3-002
ENSP00000399614
ENST00000452814
F6X994 [Direct mapping]
Rab11 family-interacting protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030139 [endocytic vesicle]
GO:0055038 [recycling endosome membrane]
Show all
 182 aa
19.6 kDa 		No 0
RAB11FIP3-004
ENSP00000412502
ENST00000412256
H0Y7F9 [Direct mapping]
Rab11 family-interacting protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030139 [endocytic vesicle]
GO:0055038 [recycling endosome membrane]
Show all
 136 aa
14.6 kDa 		No 0
RAB11FIP3-009
ENSP00000404331
ENST00000449879
A0A0A0MSV1 [Direct mapping]
Rab11 family-interacting protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030139 [endocytic vesicle]
GO:0055038 [recycling endosome membrane]
Show all
 158 aa
16.8 kDa 		No 0
RAB11FIP3-010
ENSP00000399644
ENST00000434585
X6RFI8 [Direct mapping]
Rab11 family-interacting protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0030139 [endocytic vesicle]
GO:0055038 [recycling endosome membrane]
Show all
 677 aa
75.9 kDa 		No 0
RAB11FIP3-201
ENSP00000415919
ENST00000450428
O75154 [Direct mapping]
Rab11 family-interacting protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0030139 [endocytic vesicle]
GO:0030306 [ADP-ribosylation factor binding]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032456 [endocytic recycling]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045171 [intercellular bridge]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0070164 [negative regulation of adiponectin secretion]
Show all
 460 aa
52.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.